Innovation Management Journal

Innovation Management Journal

Mapping key stakeholder interactions of biopharmaceutical technological innovation

Document Type : Original Article

Authors
1 Assistant Professor, Policy evaluation and Monitoring of Science, Technology, and Innovation Department, National Research Institute for Science Policy (NRISP), Tehran, Iran. (Corresponding author). azadi@nrisp.ac.ir
2 Department of Technology Management, Faculty of Management and Economics, Science and Research Branch, Islamic Azad University, Tehran, Iran. m.behifar@gmail.com
Abstract
The biopharmaceutical industry has a special position among modern industries and the speed of development of its applications is surprising and has a wide range of capabilities and field of action. Therefore, in the current research, the interactions of the key stakeholders were analyzed with technological innovation approach, structural analysis model and Micmac software. Therefore, the set of key stakeholders effective in the development of technological innovation biological drugs were identified and then they were classified based on the power of influence and dependence. The key stakeholders of the field of biological drugs are five categories of main actors, policy field, educational and research system, active companies, financial system, support and regulatory system. After distributing and completing the questionnaires, it was collected by 28 key informants. The results showed that the relations for the development of technological innovations can be such that the internal research and development centers affiliated to the government, responsible for research and development; Private companies are in charge of producing products and government ministries are in charge of marketing through the formulation of regulations and standards that create monopoly or the imposition of tariffs or the purchase of local products, which can be accompanied by changes in the level of cooperation with the level of capability of private companies producing biological drugs or government institutions involved.
Keywords
Subjects

باقری‌مقدم، ناصر، موسوی درچه، سیدمسلم، نصیری، مسعود، معلمی، عنایت‌اله، و رادپور، سعیدرضا (1393). موتورهای محرک نوآوری: چارچوبی خلاقانه برای تحلیل پویایی نظام‌های نوآوری فناورانه. تهران: مرکز تحقیقات سیاست علمی کشور.
تفرشی، سیّدحسام‌الدّین (1401). تعریف زیست داروها (داروهای بیولوژیک). سازمان نظام پزشکی شهریار، https://npshahriar.ir
رستمی، رضا، رضایی، بیژن، و دل‌انگیزان، سهراب (1400). تحلیل تعامل بازیگران خوشه‌های کسب‌وکار دوسوتوان: شناسایی راهبردها با نظریه بازی‌ها. مدیریت نوآوری، 10(4)، 120-89. https://www.nowavari.ir/article_145345.html
شیخ علیا لواسانی، سجاد، و دهقان نیری، محمود (1402). مدل‌سازی تعاملات ذی‌نفعان کلیدی امنیت غذایی در بخش دانه‌های روغنی با رویکرد ساختاردهی مسئله. مدیریت صنعتی، 15(3)، 446-411.doi: 10.22059/imj.2023.351740.1008006
طباطبائیان، سیدحبیب‌الله، طهوری، حمیدرضا، تقوا، محمدرضا، و تقوی‌فرد، سیدمحمدتقی (1397). تحلیل اکوسیستم نوآوری داروهای زیستی در ایران. فصلنامه مدیریت توسعه فناوری، 6(1)، 45-9. doi: 10.22104/jtdm.2018.2582.1874
کریملو، رضا، و ذاکری، امیر (1399). تحلیل تعاملات میان ذی‌نفعان کلیدی در یک نظام نوآوری منطقه‌ای (مطالعه موردی: منطقه ویژه علم و فناوری ربع رشیدی. بهبود مدیریت، (4)14، 112-83. doi: 10.22034/jmi.2021.120056
محمدی، مهدی، یزدانی، حمیدرضا، و اجاقی، حامد (1398). شناسایی بازیگران اصلی و نقش‌های کلیدی در زیست بوم نوآوری نوپاها: مطالعه‌ای در استان همدان. مدیریت نوآوری، 8(1)، 21-56. SID. https://sid.ir/paper/241487/fa
نصیری، حسین، یمنی دوزی سرخابی، محمد، ذاکرصالحی، غلامرضا، و ابوالقاسمی، محمود (1401). تحلیل تعاملات پیش‌بینی‌شده ذی‌نفعان علم و فناوری در قوانین و اسناد بالادستی. فرایند مدیریت و توسعه، 35 (3)، 195-165. doi:10.52547/jmdp.35.3.165
Arranz, N., Arroyabe, M.F., Schumann, M (2020). The role of NPOs and international actors in the national innovation system: A network-based approach, Technological Forecasting and Social Change, 159, 120183. https://doi.org/10.1016/j.techfore.2020.120183
Bergek, A (2019). Technological innovation systems: a review of recent findings and suggestions for future research. Handbook of sustainable innovation, 200-218.
Bergek, A., M. Hekkert, S. Jacobsson, J. Markard, B. Sandén and B. Truffe (2015). Technological innovation systems in contexts: Conceptualizing contextual structures and interaction dynamics’, Environmental Innovation and Societal Transitions, 16, 51- 64. https://doi.org/10.1016/j.eist.2015.07.003
Bergek, A., S. Jacobsson, B. Carlsson, S. Lindmark and A. Rickne (2008). Analyzing the functional dynamics of technological innovation systems: A scheme of analysis’, Research Policy, 37 (3), 407-29. https://doi.org/10.1016/j.respol.2007.12.003
Binz, C., B. Truffer and L. Coenen (2014). Why space matters in technological innovation systems—Mapping global knowledge dynamics of membrane bioreactor technology’, Research Policy, 43 (1), 138-55. http://dx.doi.org/10.1016/j.respol.2013.07.002
Binz, C., B. Truffer, L. Li, Y. Shi, and Y. Lu (2012). Conceptualizing leapfrogging with spatially coupled innovation systems: The case of onsite wastewater treatment in China’, Technological Forecasting and Social Change, 79 (1), 155-71. https://doi.org/10.1016/j.techfore.2011.08.016
Blum, N.U., C.R. Bening and T.S. Schmidt (2015). An analysis of remote electric mini-grids in Laos using the Technological Innovation Systems approach. Technological Forecasting and Social Change, 95 (0), 218–33. http://dx.doi.org/10.1016/j.techfore.2015.02.002
Bröring, S., L. Martin Cloutier and J. Leker (2006). The front end of innovation in an era of industry convergence: evidence from nutraceuticals and functional foods. R&D Management, 36 (5), 487-98. http://dx.doi.org/10.1111/j.1467-9310.2006.00449.x
Carayannis, E. G., & Campbell, D. F (2009). Mode 3'and'Quadruple Helix': toward a 21st century fractal innovation ecosystem. International journal of technology management, 46(3-4), 201-234. http://dx.doi.org/10.1504/IJTM.2009.023374
Carlsson, B. (ed.) (1995). Technological Systems and Economic Performance: The Case of Factory Automation, Dordrecht: Kluwer Academic Publishers.
Carlsson, B. and R. Stankiewicz (1991). On the nature, function and composition of technological systems. Journal of Evolutionary Economics, 1 (2), 93-118.
Carlsson, B. and R. Stankiewicz (1995). On the Nature, Function and Composition of Technological Systems’, in Bo Carlsson (ed.), Technological systems and economic performance: the case of factory automation, Dordrecht: Kluwer Academic Publishers, 21-56.
Carlsson, B., L. Elg and S. Jacobsson (2010). Reflections on the co-evolution of innovation theory, policy and practice: the emergence of the Swedish agency for innovation systems’, in Ruud E. Smits, Stefan Kuhlmann and Philip Shapira (eds.), The theory and practice of innovation policy. An international research handbook, Cheltenham: Edward Elgar, 145-66. http://dx.doi.org/10.4337/9781849804424.00014
Carlsson, B., S. Jacobsson, M. Holmén and A. Rickne (2002). Innovation systems: analytical and methodological issues. Research Policy, 31, 233-45. https://doi.org/10.1016/S0048-7333(01)00138-X
Cho, A., & Park, S (2022). Exploring the Global Innovation Systems Perspective by Applying Openness Index to National Systems of Innovation. Journal of Open Innovation: Technology, Market, and Complexity, 8(4), 181. https://doi.org/10.3390/joitmc8040181
Coenen, L., P. Benneworth, and B. Truffer (2012). Toward a spatial perspective on sustainability transitions’, Research Policy, 41 (6), 968-79. http://dx.doi.org/10.1016/j.respol.2012.02.014
de Arroyabe, J. C. F., Schumann, M., Sena, V., & Lucas, P (2021). Understanding the network structure of agri-food FP7 projects: An approach to the effectiveness of innovation systems. Technological Forecasting and Social Change, 162, 120372. https://doi.org/10.1016/j.techfore.2020.120372
Dewald, U. and M. Fromhold-Eisebith (2015). Trajectories of sustainability transitions in scale-transcending innovation systems: The case of photovoltaics’, Environmental Innovation and Societal Transitions, 17, 110-25. http://dx.doi.org/10.1016%2Fj.eist.2014.12.004
Dudin, M. N (2013). The Intellectual Factor and Its Defining Role in Boosting the Competitiveness of Entrepreneurial Establishments. European Researcher, 38(11), 15-19.
Dudin, M. N., Lyasnikov, N. V., Pankov, S. V., & Sepiashvili, E. N (2013). Innovative foresight as an instrument for the sustainable development of entrepreneurial establishments. World Applied Sciences Journal, 26(8), 1086-1089. http://dx.doi.org/10.5829/idosi.wasj.2013.26.08.13550
Dudin, Mihail and Lyasnikov, Nikolay and Kuznecov, Aleksandr and Fedorova, Irina, Innovative Transformation and Transformational Potential of Socio-Economic Systems (2013). Middle East Journal of Scientific Research. – Vol. 17, № 10. – P. 1434-1437. https://ssrn.com/abstract=2574440
Edquist, C., and and B. Johnson (1997). Institutions and Organizations in Systems of Innovation’, in Charles Edquist (ed.), Systems of Innovation: Technologies, Institutions and Organizations, London: Pinter Publishers, 41-63.
Edsand, H. E (2019). Technological innovation system and the wider context: A framework for developing countries. Technology in Society, 58, 101150. https://doi.org/10.1016/j.techsoc.2019.101150
Edsand, H.-E (2017). Identifying barriers to wind energy diffusion in Colombia: A function analysis of the technological innovation system and the wider context’, Technology in Society, 49, 1-15. https://doi.org/10.1016/j.techsoc.2017.01.002
Eggink, M (2013). The components of an innovation system: A conceptual innovation system framework. Journal of Innovation and Business Best Practices, 2013, 1-12.
Eliasson, G (1997). Competence Blocs and Industrial Policy in the Knowledge Based Economy’, mimeo, Stockholm: The Royal Institute of Technology, Department of Industrial Economics and Management.
Etzkowitz, H., & Leydesdorff, L (2000). The dynamics of innovation: from National Systems and “Mode 2” to a Triple Helix of university–industry–government relations. Research policy, 29(2), 109-123. https://doi.org/10.1016/S0048-7333(99)00055-4
Feng B., Sun K., Chen M., and Gao T (2020). The impact of core technological capabilities of high-tech industry on sustainable competitive advantage, Sustainability. 12, no. 7, 2980. https://doi.org/10.3390/su12072980
Hassani, S. H., Rafiei, S. H., & Bakhshiani, A (2016). Investigating the Role of Research and Technology Organizations in National Innovation System; Case Study of Research Institute of Petroleum Industry. Journal of Science and Technology Policy, 9(4), 63-76. https://dor.isc.ac/dor/20.1001.1.20080840.1395.9.4.6.4
Hekkert, M.P., R.A.A. Suurs, S.O. Negro, S. Kuhlmann and R.E.H.M. Smits (2007). Functions of innovation systems: A new approach for analyzing technological change. Technological Forecasting and Social Change, 74 (4), 413-32. https://doi.org/10.1016/j.techfore.2006.03.002
Hughes, T.P (1983). Networks of power: Electrification in Western Society, 1880-1930, Baltimore: The Johns Hopkins University Press.
Hughes, T.P (1990). The Evolution of Large Technological Systems’, in Wiebe E. Bijker, Hughes, Thomas P. and Pinch, Trevor. J. (ed.), The Social Construction of Technological Systems: New Directions in the Sociology and History of Technology, Cambridge, Massachusetts: The MIT Press, 51-82.
Jacobsson, S. and A. Bergek (2004). Transforming the energy sector: the evolution of technological systems in renewable energy technology. Industrial and Corporate Change, 13 (5), 815-49. http://dx.doi.org/10.1093/icc/dth032
Johnson, A. and S. Jacobsson (2001). Inducement and Blocking Mechanisms in the Development of a New Industry: The Case of Renewable Energy Technology in Sweden, in R. Coombs, et al. (eds.), Technology and the Market: Demand, Users and Innovation, Cheltenham/Northhampton: Edward Elgar.
Jun, S. P., Lee, J. S., & Lee, J (2020). Method of improving the performance of public-private innovation networks by linking heterogeneous DBs: Prediction using ensemble and PPDM models. Technological Forecasting and Social Change, 161, 120258. https://doi.org/10.1016/j.techfore.2020.120258
Kemp, R., J. Schot, and R. Hoogma (1998). Regime shifts to sustainability through processes of niche formation: The approach of strategic niche management’, Technology Analysis & Strategic Management, 10 (2), 175-98.
König, B., Janker, J., Reinhardt, T., Villarroel, M., & Junge, R (2018). Analysis of aquaponics as an emerging technological innovation system. Journal of cleaner production, 180, 232-243. https://doi.org/10.1016/j.jclepro.2018.01.037
Lundvall, B. Å (2016). National innovation systems and globalization. The learning economy and the economics of hope, 351. https://www.jstor.org/stable/j.ctt1hj9zjd
Lundvall, B.-Å (1992). Introduction’, in Bengt-Åke Lundvall (ed.), National Systems of Innovation - toward a Theory of Innovation and Interactive Learning. London: Pinter Publishers, 1-19
Lundvall, B.-A. Technical Change and Economic Theory. Date Views 20.11.2023 www.freemanchris.org/publication.
Mäkitie, T., A.D. Andersen, J. Hanson, H.E. Normann and T.M. Thune (2018). Established sectors expediting clean technology industries? The Norwegian oil and gas sector's influence on offshore wind power. Journal of Cleaner Production, 177, 813-23. http://dx.doi.org/10.1016/j.jclepro.2017.12.209
Markard, J., R. Raven and B. Truffer (2012). Sustainability transitions: An emerging field of research and its prospects. Research Policy, 41 (6), 955-67. https://doi.org/10.1016/j.respol.2012.02.013
Maruccia, Y., Solazzo, G., Del Vecchio, P., Passiante, G (2020). Evidence from Network Analysis application to Innovation Systems and Quintuple Helix, Technological Forecasting and Social Change, 161, 120306. https://doi.org/10.1016/j.techfore.2020.120369
Mavi, R.K, Mavi, N.K (2021). National eco-innovation analysis with big data: A common-weights model for dynamic DEA, Technological Forecasting and Social Change, 162, 120369. https://doi.org/10.1016/j.techfore.2020.120369
Nelson, R.R (1992). National Innovation Systems: A Retrospective on a Study’, Industrial and Corporate Change, 1 (2), 347-74. DOI:10.1093/ICC/1.2.347
Pavitt, K (1984). Sectoral patterns of technical change: towards a taxonomy and a theory. Research policy, 13(6), 343-373.
Porter, M (1990). The competitive advantage of nations’, Harvard Business Review, 68 (2), 73-93.
Rotaba, Z., & Beaudry, C (2012). How do high, medium, and low-tech firms innovate? A system of innovation (Si) approach. International Journal of Innovation and Technology Management, 9(05), 1250034. DOI:10.1142/S0219877012500344
Rothwell, R (1977). The characteristics of successful innovators and technically progressive firms (with some comments on innovation research). R&D Management, 7(3), 191-206. https://doi.org/10.1111/j.1467-9310.1977.tb01334.x
 Ryan, Michael P.; Walsh, Gary (2012). Veterinary-based biopharmaceuticals. Trends in Biotechnology 30 (12): 615–620. doi:10.1016/j.tibtech.2012.08.005
Sabatier, P.A (1998). The advocacy coalition framework: revisions and relevance for Europe. Journal of European Public Policy, 5 (1), 98-130. https://doi.org/10.1080/13501768880000051
Scott, W.R (1995). Institutions and Organizations, Thousand Oaks: Sage Publications. Stephan, A., T.S.
Sengupta, A., Sena, V (2020). Impact of open innovation on industries and firms – A dynamic complex systems view, Technological Forecasting and Social Change, 20, 120199. https://doi.org/10.1016/j.techfore.2020.120199
Stephan, A., T.S. Schmidt, C.R. Bening and V.H. Hoffmann (2017). The sectoral configuration of technological innovation systems: Patterns of knowledge development and diffusion in the lithium-ion battery technology in Japan’, Research Policy, 46 (4), 709-23. https://doi.org/10.1016/j.respol.2017.01.009
The UN and Sustainable Development. The official website of the United Nations. Date Views 20.10.2024, www.un.org/ru/development/sustainable/.
Van de Ven, A.H (1993). The Development of an Infrastructure for Entrepreneurship’, Journal of Business Venturing, 8, 211-30.
Walsh, Gary (2018). Biopharmaceutical benchmarks 2018. Nature Biotechnology, 36 (12): 1136-1145. doi:10.1038/nbt.4305.
Yao, L., Li, J., Li, J (2020). Urban innovation and intercity patent collaboration: A network analysis of China’s national innovation system, Technological Forecasting and Social Change, 160, 120185. https://doi.org/10.1016/j.techfore.2020.120185

  • Receive Date 15 February 2024
  • Revise Date 28 September 2024
  • Accept Date 29 April 2024