An Analysis on Technological Innovation System Regarding Iranian Bio-Products (Focused on Human Vaccines)

Document Type : Original Article

Authors

1 Ph.D. Candidate / Department of Technology Management, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Associate Professor / Department of Management, Faculty of Management and Accounting, Allameh Tabatabaei University, Tehran, Iran

3 Associate Professor / Department of Educational administration, Science and Research branch, Islamic Azad University, Tehran, Iran,

4 Assistant Professor / Pasteur institute of IRAN, Tehran, Iran

Abstract

Regarding strategic importance of biotechnology in world’s economy, Iran has made investments in this field since twenty years ago which resulted in several achievements. This paper is going to analyze the domestic efforts in Biotech industry and the quality of innovation system evolution, focusing on vaccine production, based on seven innovation key functions introduced by Bergek, et al. (2007). The importance of Biotech industry, its market condition and a brief history of domestic human vaccine production is presented. After addressing the necessity for the country to enter in this high-tech industry, which was commenced with technology transfer project for production of HB vaccine, the functions of its innovation system will be investigated and the results will be discussed by historical data mapping method. Situation of domestic vaccine production innovation system with regard to the blocking and inducement mechanisms at functional level will be analyzed by Delphi method and policy making issues will be pointed out finally. Accordingly to inhibit 8 blocking mechanisms and stimulate 3 inducement mechanisms, 6 political issues were recommended.

Keywords

Main Subjects


Aldrich, H., Fiol, C., 1994, Fools rush in? The institutional context of industry creation, Academy of Management Review, 19 (4), pp. 645-670.
AndrusWagstaff, 2014. Andrus Wagstaff. [Online]. Available at: https://www.andruswagstaff.com/blog/big-pharma-has-higher-profit-margins-than-any-other-industry/. [Accessed 2014].
Bergek, A., Jacobsson, S., 2003, The Emergence of a Growth Industry: A Comparative Analysis of the German, Dutch and Swedish Wind Turbine Industries, In: S. Metcalfe and U. Cantner (Eds.), Change, Transformation and Development, Physica-Verlag, Heidelberg, pp. 197-227.
Bergek, A., Jacobsson, S., Carlsson, B., Lindmark, S., Rickne, A., 2007, Analyzing the dynamics and functionality of sectoral innovation systems: a manual for policy makers, VINNOVA (the Swedish Agency for Innovation Systems).
Bergek, A., Jacobsson, S. and Hekkert, M., 2007, Functions in innovation systems: a framework for analyzing energy system dynamics and identifying goals for system-building activities by entrepreneurs and policy makers, In: T. Foxon, J. K¨ohler and C. Oughton (Eds.), Innovations for a Low Carbon Economy: Economic, Institutional and Management Approaches, Edward Elgar, Cheltenham.
Breschi, S., Malerba, F., 2001, The geography of innovation and economic clustering: some introductory notes, Industrial and corporate change, 10 (4), pp.817-833.
Carlsson, B., Stankiewicz, R., 1991, On the nature, function, and composition of technological systems, Journal of Evolutionary Economics, Volume (I), pp. 93-108.
Dobos. E, Grønning. T, Knell.M, Olsen.D.S., Veistein, B.K, 2004, Case study on Biotech innovation systems - Norway, Vol. 1: Biopharmaceuticals, Centre for Technology, Innovation and Culture, DSTI/STP/TIP(2002), University of Oslo, Norway.
Enzing C., van der Giessen A., Kern S., 2004, The Dutch Pharmaceutical and Food Biotechnology Innovation Systems, TNO report, STB-04-12, Nederland.
Euler Hermes Economic Research, Pharmaceuticals global sector report, Feb.2017, http://www.eulerhermes.com/economic-research/sector-risks/Global-Pharmaceuticals-Report/Pages/default.aspx.
Lippincott Williams & Wilkins, 2013. Fact and Comparison in Industries: Pharmaceuticals, Chap: Market research, , Sixty-Eighth edition.
Feldman, M., Schreuder, Y., 1996, Initial advantage: the origins of the geographic concentration of the pharmaceutical industry in the Mid-Atlantic region, Industrial and corporate change, 5(3), pp.839-862.
Fontenay, C.de. Carmell, E., 2001, Captured-Palestine Silicon Wadi: the forces behind cluster formation, SIEPR discussion paper No. 00-40, Stanford Institute of Economic Policy Research, Stanford, USA.
Food and Drug Administration, 2014. State Pharmacological Record, Ministry of Health and Medical Education, Iran
Ghodsi.M, 1350, 50-year history of the Pasteur Institute of Iran, Tehran, Pasteur Institute of Iran.
Haji Hosseini H., Mohammadi M., Abassi.F., Elyasi.M., Autumn 2011.  Analysis of Iranian Innovation System's Governance Based on Innovation Policy Making Cycle. Journal of Science and Technology Policy, 4(1), pp. 33-48.
Healing Online News Agency, 2014. Healing Online. [Online] Available at: http://shafaonline.ir/en/news/35956. [Seen in 2017].
Health Technology Council, 1393. Status of Resistance Economics in Health, Resistance Economics Team.
HSBC contributor, 2014, HSBC Voice: Crowdfunding’s Untapped Potential in Emerging Markets, Forbes, August 5.
Hung, H.L, Altschuld.J.W, Lee, Y.F., 2008, Methodological and conceptual issues confronting a cross-country Delphi study of educational program evaluation. Evaluation and Program Planning, Volume (31), pp.191–198.
Huzair. F, Sturdy. S., 2017, Biotechnology and the transformation of vaccine innovation: The case of the hepatitis B vaccines 1968-2000, Studies in History and Philosophy of Biological and Biomedical Sciences, Volume (64), pp.11-21.
Islami.V., Marandi V., 1998.  Hepatitis B vaccine production project, the economic foundations of clean spaces in the country and self-sufficiency efforts, 2nd International Conference on clean rooms and filter engineering: Amirkabir University of Technology - Tehran.
IranBioTech Festival, 2015, Biotechnology Science situation report in Iran, IRAN.
Jansma.S.R., Gosselt.J.F., De Jong.M.D.T., 2018, Technological start-ups in the innovation system: an actor-oriented perspective, Technology Analysis  & Strategic Management, 30(3), pp.282–294.
Marandi, 2003. Identification of relative advantages and investment opportunities in the country, Creating an effective approach to research and development, Fourth international conference of research and development centers: Society of research and development centers for mines and industries - Ministry of Science, Research and Technology - Ministry of Industry And mines.
Marandi, V., 2001. Biotechnology Industrial Development in the Country, Importance and Solutions, Second National Biotechnology Conference: Ministry of Science, Research and Technology, National Center for Genetic Engineering and Biotechnology Research.
Marandi, V., 2004a.  A case study of goals realization and analysis of managerial approaches in a national development project, Second International Management Conference: Sharif University of Technology - Iranian Industrial Development and Renovation Organization, Ariana Industrial Research Group.
Marandi,V., 2004b.  Loghmani's Viewpoint: A Successful Strategic Case Study on the Realization of Goals in a National Project, Fifth Quality Management Conference: Institute of Standards and Industrial Research of Iran, Organization for Management and Planning, Research Process.
Marandi, 2005, Analysis of Knowledge Management Component in a National Strategic Project, Fifth International Conference on Research and Development Centers: Society of Research and Development Centers of Industries and Mines, Ministry of Science, Research and Technology, Ministry of Industry and Mines.
Marandi V., 2015.  An Analysis of the State of Innovation in the Production of Vaccines in the Country, the Collection of Science and Technology Policies: Islamic Azad University, Science and Research Branch of Tehran.
Mohammadpour, A., 2010.The Evaluation of Quality in Qualitative Research: the Principles and Strategies of Validation and Generalization. Quarterly Journal of Social Sciences, Volume - , Number 48, pp. 73 -105.
Mohammadi, M., Eliasy, M., Taghavi Fard. M. Haji Hosseini, Delaware. AS., 2012.Modeling the Formation of Technological Innovation System in the Iranian Biotechnology Sector Using Structural Equation Modeling.
Mesa. E.G, 2004, Study on the national innovation system in the Spainish biopharmaceutical sector, UEM, DSTI/STP/TIP (2002)1 – OECD, Spain.
Motohashi, K, 2004, OECD/TIP Project on Biopharmaceutical National Innovation Systems, National Report: Japan, OECD/TIP, Tokyo, Japan.
National Biotechnology Development Agency, 2013. Operational Program Vaccine Working Group, Tehran.
Okoli.C, Pawlowski.S.D, 2004, The Delphi method as a research tool: An example, design considerations and applications, Information & Management, 42(1), pp. 15-29.
Office of Biotechnology Development, 2016. Evaluation and Evaluation of Scientific Documentation of Biotechnology in Iran and the World (1996-2015). Chair of the Vice-President of Science and Technology.
Porter, M., 1998, Clusters and competition: new agendas for companies, governments and institutions, On Competition, Boston: Harvard Business School Press, pp. 197-287.
Powell, C, 2003, Myths and realities of the Delphi technique, J Adv Nurs, Volume (41), pp. 376–382.
Qasem Sharbani, M., Radfarr., Abedi, Z., 2010, The Appropriate Model of Biotechnology Commercialization in the Field of Environment in Iran, The 4th National Conference on Technology Management of Iran, Technology Management Association of Iran, Tehran .
Rao, H., 2004,  Institutional activism in the early American automobile industry, Journal of Business Venturing, 19 (3), pp. 359-384.
Reiss, T., Hinze.S., 2004, Case study on biotechnology innovation systems: National Report Germany, Fraunhofer Institute for Systems and Innovation Research, Germany.
Rochepeau, A., 2004, The Pharmaceutical Biotechnology Industry in France, French Ministry of Research and New Technologies, France.
Sarmad.Z., Bazargan A., Hejazi, A., 2005, Research Methods in Behavioral Sciences, Tenth Edition, Tehran:Agah Publishing.
Statista, 2016. Statista. [Online]. Available at: https://www.statista.com/statistics/272717/top-global-biotech-and-pharmaceutical-companies-based-on-revenue/ [Accessed 2016].
Van de Van, A., 2005, Running in packs to develop knowledge-intensive technologies, MIS Quarterly, 29 (2), pp.365-378.
Van Teijlingen, E., Pitchforth, E., Bishop, C., Russell, E., 2006 Oct., Delphi method and nominal group technique in family planning and reproductive health research, J Fam Plann Reprod Health Care; 32(4), 249-52.
Von Blankenfeld-Enkvist, G, Brännback, M., Söderlund, R., Petrov, M., 2004, OECD Case Study on Innovation: The Finnish Biotechnology Innovation System, INNOMARKET, Finland.
Windisch, P., 2015, Biosimilars versus original biologics. Similarities and differences from development to approval, Z Rheumatol. 74(8), pp.672-81. doi: 10.1007/s00393-014-1486-9.
Windle, P.E., 2004 Feb; Delphi technique: assessing component needs, J Perianesth Nurs, 19(1), pp. 46-47.
Woolthuis, R.K., Lankhuizen, M, Gilsing, V., 2005, A system failure framework for innovation policy design, Technovation, 25 (6), pp.609-619.
Zimmerman, M., Zeitz, G., 2002, Beyond survival: achieving new venture growth by building legitimacy, Academy of Management Review, 27 (3), pp. 414-431.